KMID : 0363220110490121125
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Korean Journal of Dermatology 2011 Volume.49 No. 12 p.1125 ~ p.1127
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Vesicles in Chronic Graft-versus-host Disease
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Hong Boo-Hwi
Jeong Nam-Ji Im Myung Lee Young Seo Young-Joon Lee Jeung-Hoon
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Abstract
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Chronic graft-versus-host disease (GVHD) usually presents 100 days after allogenic bone marrow transplantation. Chronic GVHD cutaneous lesions are characterized by lichenoid or sclerodermoid variants. Vesicles, a common presentation in patients with acute GVHD, rarely appear in chronic GVHD. We report a case of a 49-year-old man who presented with bilateral vesicles on lower extremities. He was diagnosed with myelodysplastic syndrome 2 years before and was taking oral cyclosporine after the allogenic bone marrow transplantation. Six months post-transplantation, lichenoid and sclerodermoid lesions developed on his entire body and he was diagnosed with chronic GVHD and eosinophilic fasciitis. A biopsy of the vesicles revealed detached lower margins of the epidermis, necrotized keratinocytes, and infiltration of lymphocytic inflammatory cells. Administration of oral prednisolone alleviated the patient¡¯s symptoms. This is an interesting case showing a new pattern of vesicle appearance after development of typical chronic GVHD lesions.
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KEYWORD
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Chronic GVHD, GVHD, Vesicle
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